|Other Accession||NM_003485, NP_003476|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Dog|
|Alias Symbol||MGC111379, MGC156983, OGR1, GPR12A|
|Other Names||Ovarian cancer G-protein coupled receptor 1, OGR-1, G-protein coupled receptor 68, GPR12A, Sphingosylphosphorylcholine receptor, GPR68, OGR1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-GPR68 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||GPR68 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system.|
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Provided below are standard protocols that you may find useful for product applications.
An S.,et al.FEBS Lett. 375:121-124(1995).
Xu Y.,et al.Genomics 35:397-402(1996).
Kaighin V.A.,et al.Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
King M.M.,et al.Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
Heilig R.,et al.Nature 421:601-607(2003).
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