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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HTRA3 antibody - middle region   

HTRA3 antibody - middle region

Rabbit Polyclonal Antibody

  • WB - HTRA3 antibody - middle region AI15121

    WB Suggested Anti-HTRA3 Antibody Titration: 1.0 μg/ml
    Positive Control: Fetal Brain
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P83110
Other Accession NM_053044, NP_444272
Reactivity Human, Mouse, Rat, Horse, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Pig, Horse, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 47kDa
Additional Information
Gene ID 94031
Alias Symbol Prsp, Tasp
Other Names Serine protease HTRA3, 3.4.21.-, High-temperature requirement factor A3, Pregnancy-related serine protease, HTRA3, PRSP
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-HTRA3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsHTRA3 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HTRA3
Synonyms PRSP
Function Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization.
Cellular Location Secreted. Note=Secretion increased during decidualization of endometrial stromal cells
Tissue Location Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney.
Research Areas
Citations (0)

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Nie G.-Y.,et al.Biochem. J. 371:39-48(2003).
Southan C.,et al.Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Bowden M.A.,et al.Gynecol. Oncol. 103:253-260(2006).
Narkiewicz J.,et al.Oncol. Rep. 21:1529-1537(2009).

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$ 293.00
Cat# AI15121
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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