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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CILP antibody - C-terminal region   

CILP antibody - C-terminal region

Rabbit Polyclonal Antibody

  • WB - CILP antibody - C-terminal region AI15140

    WB Suggested Anti-CILP Antibody Titration: 1.0 μg/ml
    Positive Control: 721_B Whole Cell
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75339
Other Accession NM_003613, NP_003604
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 52kDa
Additional Information
Gene ID 8483
Alias Symbol CILP-1, HsT18872
Other Names Cartilage intermediate layer protein 1, CILP-1, Cartilage intermediate-layer protein, Cartilage intermediate layer protein 1 C1, Cartilage intermediate layer protein 1 C2, CILP
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-CILP antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsCILP antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Specifically expressed in cartilage. Localizes in the intermediates layer of articular cartilage but neither in the superficial nor in the deepest regions. Specifically and highly expressed in intervertebral disk tissue. Expression increases with aging in hip articular cartilage. Overexpressed in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease (CPPD) Expression in intervertebral disk tissue from individuals with lumbar disk disease increases as disk degeneration progresses
Research Areas
Citations (0)

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Lorenzo P.,et al.J. Biol. Chem. 273:23469-23475(1998).
Nakamura I.,et al.J. Hum. Genet. 44:203-205(1999).
Lorenzo P.,et al.Matrix Biol. 18:445-454(1999).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 293.00
Cat# AI15140
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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