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GSPT1 Antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - GSPT1 Antibody - N-terminal region AI15164

    WB Suggested Anti-GSPT1 Antibody Titration: 1.0 μg/ml
    Positive Control: HepG2 Whole CellGSPT1 is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P15170
Other Accession NM_001130006, NP_001123478
Reactivity Human, Rat, Rabbit, Pig, Bovine, Dog
Predicted Human, Rat, Rabbit, Pig, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 70kDa
Additional Information
Gene ID 2935
Alias Symbol 551G9.2, ETF3A, FLJ38048, FLJ39067, GST1, eRF3a
Other Names Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, Eukaryotic peptide chain release factor subunit 3a, eRF3a, G1 to S phase transition protein 1 homolog, GSPT1, ERF3A
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-GSPT1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsGSPT1 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GSPT1
Synonyms ERF3A
Function GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:2511002, PubMed:15987998, PubMed:19417105, PubMed:27863242). GSPT1/ERF3A mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:27863242). GTP hydrolysis by GSPT1/ERF3A induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A- site (PubMed:16777602, PubMed:27863242). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371).
Citations (0)
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References

Hoshino S.,et al.EMBO J. 8:3807-3814(1989).
Loftus B.J.,et al.Genomics 60:295-308(1999).
Martin J.,et al.Nature 432:988-994(2004).
Yamashita A.,et al.Genes Dev. 23:1091-1105(2009).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).

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$ 389.00
Cat# AI15164
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