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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   TCAM2 Antibody - N-terminal region   

TCAM2 Antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - TCAM2 Antibody - N-terminal region AI15166

    Host: Rabbit
    Target Name: TCAM2
    Sample Tissue: Fetal Lung lysates
    Antibody Dilution: 1.0μg/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86XR7
Reactivity Human
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW 25kDa
Additional Information
Gene ID 100302736;353376
Alias Symbol TICAM2, TIRAP3, TIRP, TRAM,
Other Names TIR domain-containing adapter molecule 2, TICAM-2, Putative NF-kappa-B-activating protein 502, TRIF-related adapter molecule, Toll-like receptor adaptor protein 3, Toll/interleukin-1 receptor domain-containing protein, MyD88-4, TICAM2, TIRAP3, TIRP, TRAM
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 &mu, l of distilled water. Final Anti-TCAM2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsTCAM2 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.
Cellular Location Isoform 1: Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic reticulum. Early endosome membrane. Late endosome membrane. Note=Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane. Upon LPS stimulation colcoalizes with isoform 2 in late endosomes
Tissue Location Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1)
Research Areas
Citations (0)

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Bin L.-H.,et al.J. Biol. Chem. 278:24526-24532(2003).
Oshiumi H.,et al.J. Biol. Chem. 278:49751-49762(2003).
Fitzgerald K.A.,et al.J. Exp. Med. 198:1043-1055(2003).
Fitzgerald K.A.,et al.J. Exp. Med. 198:1451-1451(2003).
Nakajima T.,et al.Immunogenetics 60:727-735(2008).

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$ 293.00
Cat# AI15166
(40 western blots)
Availability: 2-3 days
Bulk Size
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