|Other Accession||NM_001080496, NP_001073965|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Other Names||RAB6A-GEF complex partner protein 2, Retrograde Golgi transport protein RGP1 homolog, RGP1 (HGNC:21965), KIAA0258|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-RGP1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||RGP1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors.|
|Cellular Location||Cytoplasm, cytosol. Membrane|
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Provided below are standard protocols that you may find useful for product applications.
Nagase T.,et al.DNA Res. 3:321-329(1996).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Pusapati G.V.,et al.J. Biol. Chem. 287:42129-42137(2012).
Van Damme P.,et al.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
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