SLC22A9 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q8IVM8 |
Other Accession | NM_080866, NP_543142 |
Reactivity | Human |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 62kDa |
Gene ID | 114571 |
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Alias Symbol | FLJ23666, HOAT4, OAT4, OAT7, UST3H, ust3 |
Other Names | Solute carrier family 22 member 9, Organic anion transporter 7, SLC22A9, hOAT4, OAT7, UST3 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-SLC22A9 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | SLC22A9 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC22A9 |
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Synonyms | hOAT4, OAT7, UST3 |
Function | Sodium-independent organic anion transporter, exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones such as estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) (PubMed:17393504, PubMed:26239079, PubMed:28945155). Can transport the statin pravastatin and may contribute to its disposition into the hepatocytes when the function of OATPs is compromised (PubMed:26239079). It is specifically activated by 3 to 5 carbons- containing short-chain fatty acids/SCFAs, including propionate (propanoate), butyrate (butanoate) and valerate (pentanoate) (PubMed:17393504). May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs, in particular butanoate, at the sinusoidal membrane of hepatocytes (PubMed:17393504). |
Cellular Location | Basolateral cell membrane; Multi-pass membrane protein. Note=Enriched at the sinusoidal part of the plasma membrane |
Tissue Location | Specifically expressed in liver (also at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
References
Shin H.J.,et al.Hepatology 45:1046-1055(2007).
Engel K.,et al.Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
Takanaga H.,et al.Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
Guo J.H.,et al.Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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