|Other Accession||NM_001166245, NP_001159717|
|Reactivity||Human, Mouse, Dog|
|Predicted||Human, Mouse, Dog|
|Alias Symbol||FLJ11684, FLJ44022, HPA2, HPR2, MGC133234|
|Other Names||Inactive heparanase-2, Hpa2, HPSE2, HPA2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-HPSE2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||HPSE2 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal chord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and pons. In the urinary bladder, expressed in longitudinal and circular layers of detrusor muscle. Found both in normal and cancer tissues.|
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Provided below are standard protocols that you may find useful for product applications.
McKenzie E.,et al.Biochem. Biophys. Res. Commun. 276:1170-1177(2000).
Legoux P.,et al.Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 429:375-381(2004).
Pang J.,et al.Am. J. Hum. Genet. 86:957-962(2010).
Pang J.,et al.Am. J. Hum. Genet. 87:161-161(2010).
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