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WHAMM Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8TF30 |
| Other Accession | NM_001080435, NP_001073904 |
| Reactivity | Human, Rat, Pig, Horse, Dog |
| Predicted | Human, Rat, Pig, Horse, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 91kDa |
| Gene ID | 123720 |
|---|---|
| Alias Symbol | KIAA1971, WHDC1 |
| Other Names | WASP homolog-associated protein with actin, membranes and microtubules, WAS protein homology region 2 domain-containing protein 1, WH2 domain-containing protein 1, WHAMM, KIAA1971, WHDC1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-WHAMM antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | WHAMM Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | WHAMM |
|---|---|
| Synonyms | KIAA1971, WHDC1 |
| Function | Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration. |
| Cellular Location | Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle membrane. Golgi apparatus, cis-Golgi network. Note=Localized to a perinuclear compartment near the microtubule-organizing center (MTOC). Also detected on tubulo-vesicular structures in the cell periphery that frequently localized along microtubules. |
| Tissue Location | Expressed in brain, lung, heart, colon and kidney (at protein level) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Nagase T.,et al.DNA Res. 8:319-327(2001).
Zody M.C.,et al.Nature 440:671-675(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Campellone K.G.,et al.Cell 134:148-161(2008).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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