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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   WHAMM Antibody - C-terminal region   

WHAMM Antibody - C-terminal region

Rabbit Polyclonal Antibody

  • WB - WHAMM Antibody - C-terminal region AI15324

    WB Suggested Anti-WHAMM Antibody Titration: 1.0 μg/ml
    Positive Control: Placenta
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8TF30
Other Accession NM_001080435, NP_001073904
Reactivity Human, Rat, Pig, Horse, Dog
Predicted Human, Rat, Pig, Horse, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 91kDa
Additional Information
Gene ID 123720
Alias Symbol KIAA1971, WHDC1
Other Names WASP homolog-associated protein with actin, membranes and microtubules, WAS protein homology region 2 domain-containing protein 1, WH2 domain-containing protein 1, WHAMM, KIAA1971, WHDC1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-WHAMM antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsWHAMM Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA1971, WHDC1
Function Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule- binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration.
Cellular Location Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle membrane. Golgi apparatus, cis-Golgi network. Note=Localized to a perinuclear compartment near the microtubule-organizing center (MTOC). Also detected on tubulo-vesicular structures in the cell periphery that frequently localized along microtubules
Tissue Location Expressed in brain, lung, heart, colon and kidney (at protein level)
Research Areas
Citations (0)

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Nagase T.,et al.DNA Res. 8:319-327(2001).
Zody M.C.,et al.Nature 440:671-675(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Campellone K.G.,et al.Cell 134:148-161(2008).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).

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$ 293.00
Cat# AI15324
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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