|Other Accession||NM_175053, NP_778223|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Sheep, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Sheep, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||K6IRS4, KRT5C, KRT6IRS4|
|Other Names||Keratin, type II cytoskeletal 74, Cytokeratin-74, CK-74, Keratin-5c, K5C, Keratin-74, K74, Type II inner root sheath-specific keratin-K6irs4, Type-II keratin Kb37, KRT74, K6IRS4, KB37, KRT5C, KRT6IRS4|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-KRT74 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||KRT74 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||K6IRS4, KB37, KRT5C, KRT6IRS4|
|Function||Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).|
|Tissue Location||Highly expressed in hair follicles from scalp. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS Huxley layer, but not in Henle layer or cuticle of the IRS. In the IRS Huxley layer, it is expressed in specialized Huxley cells, termed 'Fluegelzellen, along the area of differentiated Henle cells (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Langbein L.,et al.J. Invest. Dermatol. 120:512-522(2003).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Hesse M.,et al.J. Cell Sci. 114:2569-2575(2001).
Langbein L.,et al.J. Invest. Dermatol. 126:2377-2386(2006).
If you have any additional inquiries please email technical services at firstname.lastname@example.org.