|Other Accession||NM_005606, NP_005597|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Sheep, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Sheep, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||AEP, LGMN1, PRSC1|
|Other Names||Legumain, 18.104.22.168, Asparaginyl endopeptidase, Protease, cysteine 1, LGMN, PRSC1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-LGMN antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||LGMN Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.|
|Tissue Location||Ubiquitous. Particularly abundant in kidney, heart and placenta|
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Provided below are standard protocols that you may find useful for product applications.
Chen J.-M.,et al.J. Biol. Chem. 272:8090-8098(1997).
Tanaka T.,et al.Cytogenet. Cell Genet. 74:120-123(1996).
Li W.B.,et al.Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Heilig R.,et al.Nature 421:601-607(2003).
Chen J.-M.,et al.Biochem. J. 352:327-334(2000).
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