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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LGMN Antibody - middle region   

LGMN Antibody - middle region

Rabbit Polyclonal Antibody

  • WB - LGMN Antibody - middle region AI15367

    WB Suggested Anti-LGMN Antibody Titration: 1.0 μg/ml
    Positive Control: Fetal Brain
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99538
Other Accession NM_005606, NP_005597
Reactivity Human, Mouse, Rat, Rabbit, Pig, Sheep, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Sheep, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 48kDa
Additional Information
Gene ID 5641
Alias Symbol AEP, LGMN1, PRSC1
Other Names Legumain,, Asparaginyl endopeptidase, Protease, cysteine 1, LGMN, PRSC1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-LGMN antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsLGMN Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms PRSC1
Function Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
Cellular Location Lysosome.
Tissue Location Ubiquitous. Particularly abundant in kidney, heart and placenta
Research Areas
Citations (0)

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Chen J.-M.,et al.J. Biol. Chem. 272:8090-8098(1997).
Tanaka T.,et al.Cytogenet. Cell Genet. 74:120-123(1996).
Li W.B.,et al.Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Heilig R.,et al.Nature 421:601-607(2003).
Chen J.-M.,et al.Biochem. J. 352:327-334(2000).

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$ 293.00
Cat# AI15367
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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