|Reactivity||Human, Pig, Yeast, Dog|
|Predicted||Human, Pig, Yeast, Dog|
|Other Names||Smoothelin-like protein 1, SMTNL1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 &mu, l of distilled water. Final Anti-SMTNL1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||SMTNL1 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity).|
|Cellular Location||Cytoplasm, myofibril. Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, M line. Nucleus. Note=Colocalizes with MYH2 In its unphosphorylated state, localizes to the cytoplasm (By similarity). Phosphorylation at Ser-301 promotes translocation to the nucleus (By similarity).|
|Tissue Location||Expressed in striated muscles, specifically in type 2a fibers (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Taylor T.D.,et al.Nature 440:497-500(2006).
Wooldridge A.A.,et al.J. Biol. Chem. 283:11850-11859(2008).
Lontay B.,et al.J. Biol. Chem. 285:29357-29366(2010).
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