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> home > Products > Primary Antibodies > Antibody Collections > Mitochondrion > MICU1 Antibody - C-terminal region
MICU1 Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9BPX6 |
| Other Accession | NM_001195519, NP_001182448 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Goat, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Goat, Horse, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 30kDa |
| Gene ID | 10367 |
|---|---|
| Alias Symbol | CALC, DKFZp564C246, EFHA3, FLJ12684, CBARA1 |
| Other Names | Calcium uptake protein 1, mitochondrial, Atopy-related autoantigen CALC, ara CALC, Calcium-binding atopy-related autoantigen 1, Hom s 4, MICU1, CALC, CBARA1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-MICU1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | MICU1 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MICU1 |
|---|---|
| Synonyms | CALC {ECO:0000303|PubMed:16002733}, CBAR |
| Function | Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose- dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1- mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733). |
| Cellular Location | Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space |
| Tissue Location | Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Natter S.,et al.FASEB J. 12:1559-1569(1998).
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$ 389.00
Cat# AI15388
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