|Other Accession||NM_019618, NP_062564|
|Reactivity||Human, Rabbit, Horse|
|Predicted||Human, Rabbit, Horse|
|Alias Symbol||IL-1F9, IL-1H1, IL-1RP2, IL1E, IL1F9, IL1H1, IL1RP2|
|Other Names||Interleukin-36 gamma, IL-1-related protein 2, IL-1RP2, Interleukin-1 epsilon, IL-1 epsilon, Interleukin-1 family member 9, IL-1F9, Interleukin-1 homolog 1, IL-1H1, IL36G, IL1E, IL1F9, IL1H1, IL1RP2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-IL36G antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||IL36G Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||IL1E, IL1F9, IL1H1, IL1RP2|
|Function||Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus.|
|Tissue Location||Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. Expressed in bronchial epithelial. In skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up- regulated in lesional psoriasis skin. Expressed in monocyte- derived dendritic cells and M1 macrophages|
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Provided below are standard protocols that you may find useful for product applications.
Kumar S.,et al.J. Biol. Chem. 275:10308-10314(2000).
Debets R.,et al.J. Immunol. 167:1440-1446(2001).
Busfield S.J.,et al.Genomics 66:213-216(2000).
Nicklin M.J.H.,et al.Genomics 79:718-725(2002).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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