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KIF24 Antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • WB - KIF24 Antibody - C-terminal region AI15436

    Host: Rabbit
    Target Name: KIF24
    Sample Tissue: MDA-MB-435S Whole cell lysate
    s
    Antibody Dilution: 1.0μg/mlKIF24 is supported by BioGPS gene expression data to be expressed in MDA-MB435
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q5T7B8
Other Accession NM_194313, NP_919289
Reactivity Human
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW 151kDa
Additional Information
Gene ID 347240
Alias Symbol C9orf48, bA571F15.4
Other Names Kinesin-like protein KIF24, KIF24, C9orf48
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-KIF24 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsKIF24 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KIF24
Synonyms C9orf48
Function Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419).
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole
Citations (0)

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References

Humphray S.J.,et al.Nature 429:369-374(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Daub H.,et al.Mol. Cell 31:438-448(2008).
Oppermann F.S.,et al.Mol. Cell. Proteomics 8:1751-1764(2009).
Kobayashi T.,et al.Cell 145:914-925(2011).

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$ 293.00
Cat# AI15436
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