|Other Accession||NM_182553, NP_872359|
|Reactivity||Human, Mouse, Rat, Pig, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Pig, Guinea Pig, Dog|
|Alias Symbol||CNIH-2, Cnil|
|Other Names||Protein cornichon homolog 2, CNIH-2, Cornichon family AMPA receptor auxiliary protein 2, Cornichon-like protein, CNIH2, CNIL|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-CNIH2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||CNIH2 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells).|
|Tissue Location||Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study).|
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Provided below are standard protocols that you may find useful for product applications.
Shi Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 107:16315-16319(2010).
Drummond J.B.,et al.NeuroReport 23:1031-1034(2012).
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