CNIH2 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q6PI25 |
Other Accession | NM_182553, NP_872359 |
Reactivity | Human, Mouse, Rat, Pig, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Pig, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 19kDa |
Gene ID | 254263 |
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Alias Symbol | CNIH-2, Cnil |
Other Names | Protein cornichon homolog 2, CNIH-2, Cornichon family AMPA receptor auxiliary protein 2, Cornichon-like protein, CNIH2, CNIL |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-CNIH2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | CNIH2 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CNIH2 |
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Synonyms | CNIL |
Function | Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors. |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine. Postsynaptic density. Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells). |
Tissue Location | Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study). |
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Provided below are standard protocols that you may find useful for product applications.
References
Shi Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 107:16315-16319(2010).
Drummond J.B.,et al.NeuroReport 23:1031-1034(2012).
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