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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   RRP8 Antibody - N-terminal region   

RRP8 Antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - RRP8 Antibody - N-terminal region AI15630

    Host: Rabbit
    Target Name: RRP8
    Sample Tissue: Placenta lysates
    Antibody Dilution: 1.0μg/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43159
Other Accession NM_015324, NP_056139
Reactivity Human, Rat, Rabbit, Horse, Yeast, Bovine, Guinea Pig, Dog
Predicted Human, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 50kDa
Additional Information
Gene ID 23378
Alias Symbol KIAA0409
Other Names Ribosomal RNA-processing protein 8, 2.1.1.-, Cerebral protein 1, Nucleomethylin, RRP8, KIAA0409, NML
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-RRP8 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsRRP8 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RRP8
Synonyms KIAA0409, NML
Function Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys- 9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Cellular Location Nucleus, nucleolus. Note=Localizes at rDNA locus
Research Areas
Citations (0)

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Yazaki M.,et al.Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
Ishikawa K.,et al.DNA Res. 4:307-313(1997).
Scherl A.,et al.Mol. Biol. Cell 13:4100-4109(2002).
Andersen J.S.,et al.Curr. Biol. 12:1-11(2002).
Olsen J.V.,et al.Cell 127:635-648(2006).

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$ 293.00
Cat# AI15630
(40 western blots)
Availability: 2-3 days
Bulk Size
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