|Other Accession||NM_015324, NP_056139|
|Reactivity||Human, Rat, Rabbit, Horse, Yeast, Bovine, Guinea Pig, Dog|
|Predicted||Human, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog|
|Other Names||Ribosomal RNA-processing protein 8, 2.1.1.-, Cerebral protein 1, Nucleomethylin, RRP8, KIAA0409, NML|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-RRP8 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||RRP8 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys- 9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.|
|Cellular Location||Nucleus, nucleolus. Note=Localizes at rDNA locus|
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Provided below are standard protocols that you may find useful for product applications.
Yazaki M.,et al.Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
Ishikawa K.,et al.DNA Res. 4:307-313(1997).
Scherl A.,et al.Mol. Biol. Cell 13:4100-4109(2002).
Andersen J.S.,et al.Curr. Biol. 12:1-11(2002).
Olsen J.V.,et al.Cell 127:635-648(2006).
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