|Other Accession||NM_025057, NP_079333|
|Reactivity||Human, Mouse, Rat, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Pig, Horse, Bovine, Guinea Pig, Dog|
|Other Names||Basal body-orientation factor 1, Coiled-coil domain-containing protein 176, CCDC176, BBOF1, C14orf45|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-CCDC176 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||CCDC176 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes to a polar structure adjacent to the basal body.|
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Heilig R.,et al.Nature 421:601-607(2003).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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