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>   home   >   Products   >   Primary Antibodies   >   C15orf23 Antibody - N-terminal region   

C15orf23 Antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - C15orf23 Antibody - N-terminal region AI15706

    Host: Rabbit
    Target Name: C15orf23
    Sample Tissue: MDA-MB-435S Whole cell lysate
    Antibody Dilution: 1.0μg/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y448
Other Accession NM_033286, NP_150628
Reactivity Human
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW 35kDa
Additional Information
Gene ID 90417
Alias Symbol SKAP, TRAF4AF1, C15orf23
Other Names Small kinetochore-associated protein, SKAP, Kinetochore-localized astrin-binding protein, Kinastrin, Kinetochore-localized astrin/SPAG5-binding protein, TRAF4-associated factor 1, KNSTRN (HGNC:30767)
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-C15orf23 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsC15orf23 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KNSTRN (HGNC:30767)
Function Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule- kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV- induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257).
Cellular Location Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Note=Colocalizes with microtubules around centrosomes in prophase and with the mitotic spindle at prometaphase and metaphase. From late prometaphase to anaphase, is highly concentrated on kinetochores. Located at the kinetochore-microtubule interface. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends (PubMed:23035123).
Tissue Location Widely expressed, including in skin.
Citations (0)

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Cai C.L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:671-675(2006).
Li W.B.,et al.Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
Touji S.,et al.Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.

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$ 293.00
Cat# AI15706
(40 western blots)
Availability: 2-3 days
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