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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PLD6 Antibody - C-terminal region   

PLD6 Antibody - C-terminal region

Rabbit Polyclonal Antibody

  • WB - PLD6 Antibody - C-terminal region AI15748

    Host: Rabbit
    Target Name: PLD6
    Sample Tissue: Fetal Heart lysates
    Antibody Dilution: 1.0μg/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8N2A8
Other Accession NM_178836, NP_849158
Reactivity Human
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW 28kDa
Additional Information
Gene ID 201164
Other Names Mitochondrial cardiolipin hydrolase, 3.1.-.-, Choline phosphatase 6, Mitochondrial phospholipase, MitoPLD, Phosphatidylcholine-hydrolyzing phospholipase D6, Phospholipase D6, PLD 6, Protein zucchini homolog, PLD6
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-PLD6 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsPLD6 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLD6
Function Regulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity). piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity (By similarity). Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol.
Cellular Location Mitochondrion outer membrane; Single-pass membrane protein
Tissue Location Widely expressed. Expression is not limited to testis and ovary.
Research Areas
Citations (0)

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Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Choi S.Y.,et al.Nat. Cell Biol. 8:1255-1262(2006).
Watanabe T.,et al.Dev. Cell 20:364-375(2011).
Huang H.,et al.Dev. Cell 20:376-387(2011).

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$ 293.00
Cat# AI15748
(40 western blots)
Availability: 2-3 days
Bulk Size
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