SIAH3 Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
---|---|
Primary Accession | Q8IW03 |
Other Accession | NM_198849, NP_942146 |
Reactivity | Human, Mouse, Rat, Rabbit, Horse, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Horse, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 30kDa |
Gene ID | 283514 |
---|---|
Other Names | Seven in absentia homolog 3, Siah-3, SIAH3 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-SIAH3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | SIAH3 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SIAH3 |
---|---|
Function | Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria. |
Cellular Location | Mitochondrion. |
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Provided below are standard protocols that you may find useful for product applications.
References
Dunham A.,et al.Nature 428:522-528(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hasson S.A.,et al.Nature 504:291-295(2013).
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