|Reactivity||Human, Rabbit, Pig, Horse, Bovine, Dog|
|Predicted||Human, Rabbit, Pig, Horse, Bovine, Dog|
|Alias Symbol||C8orf80, SLIP-GC|
|Other Names||Nuclear GTPase SLIP-GC, 3.6.1.-, Speckled-like pattern in the germinal center, NUGGC, C8orf80|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-NUGGC antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||NUGGC Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (PubMed:19734146). Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity).|
|Cellular Location||Nucleus speckle|
|Tissue Location||Expressed in germinal center B-cell and in lymphomas derived from germinal center B-cell|
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Provided below are standard protocols that you may find useful for product applications.
Plays a role as replication-related GTPase protein in germinal center B-cell.
Nusbaum C.,et al.Nature 439:331-335(2006).
Yamada S.,et al.Oncogene 23:5901-5911(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Richter K.,et al.J. Biol. Chem. 284:30652-30661(2009).
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