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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PIK3R6 Antibody - C-terminal region   

PIK3R6 Antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • WB - PIK3R6 Antibody - C-terminal region AI15951

    Host: Rabbit
    Target Name: PIK3R6
    Sample Tissue: 721_B Whole cell lysate
    s
    Antibody Dilution: 1.0μg/ml
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q5UE93
Other Accession NM_001010855, NP_001010855
Reactivity Human, Mouse, Rat, Pig, Horse, Guinea Pig
Predicted Human, Mouse, Rat, Pig, Horse, Guinea Pig
Host Rabbit
Clonality Polyclonal
Calculated MW 84kDa
Additional Information
Alias Symbol C17orf38, HsT41028, p84, p87(PIKAP), p87PIKAP
Other Names Phosphoinositide 3-kinase regulatory subunit 6, Phosphoinositide 3-kinase gamma adapter protein of 87 kDa, p84 PI3K adapter protein, p84 PIKAP, p87 PI3K adapter protein, p87PIKAP, PIK3R6, C17orf38
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 &mu, l of distilled water. Final Anti-PIK3R6 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsPIK3R6 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PIK3R6
Synonyms C17orf38
Function Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q3U6Q4}. Cell membrane {ECO:0000250|UniProtKB:Q3U6Q4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q3U6Q4}. Note=Translocated to the plasma membrane in a Ras-dependent manner {ECO:0000250|UniProtKB:Q3U6Q4} EMBL; AY753192; AAV30085.1; -; mRNA EMBL; AC003695; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AC009451; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AL833037; CAH56340.1; -; mRNA CCDS; CCDS73985.1; - RefSeq; NP_001010855.1; NM_001010855.3 RefSeq; XP_016879718.1; XM_017024229.1 UniGene; Hs.255809; - ProteinModelPortal; Q5UE93; - SMR; Q5UE93; - IntAct; Q5UE93; 2 iPTMnet; Q5UE93; - PhosphoSitePlus; Q5UE93; - BioMuta; PIK3R6; - DMDM; 74746772; - EPD; Q5UE93; - PeptideAtlas; Q5UE93; - PRIDE; Q5UE93; - DNASU; 146850; - Ensembl; ENST00000614407; ENSP00000482341; ENSG00000276231 Ensembl; ENST00000619866; ENSP00000480157; ENSG00000276231 GeneID; 146850; - KEGG; hsa:146850; - UCSC; uc032etf.1; human CTD; 146850; - GeneCards; PIK3R6; - HGNC; HGNC:27101; PIK3R6 HPA; HPA023077; - MIM; 611462; gene neXtProt; NX_Q5UE93; - OpenTargets; ENSG00000276231; - PharmGKB; PA162399570; - GeneTree; ENSGT00530000063753; - HOVERGEN; HBG080761; - InParanoid; Q5UE93; - OMA; IQDSKFP; - OrthoDB; EOG091G0339; - PhylomeDB; Q5UE93; - BioCyc; MetaCyc:ENSG00000174083-MONOMER; - BioCyc; ZFISH:ENSG00000174083-MONOMER; - Reactome; R-HSA-114604; GPVI-mediated activation cascade Reactome; R-HSA-1660499; Synthesis of PIPs at the plasma membrane Reactome; R-HSA-392451; G beta:gamma signalling through PI3Kgamma GenomeRNAi; 146850; - PRO; PR:Q5UE93; - Proteomes; UP000005640; Chromosome 17 Bgee; ENSG00000174083; - CleanEx; HS_PIK3R6; - ExpressionAtlas; Q5UE93; baseline and differential Genevisible; Q5UE93; HS GO; GO:0005829; C:cytosol; TAS:Reactome GO; GO:0016020; C:membrane; ISS:UniProtKB GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IBA:GO_Central GO; GO:0005944; C:phosphatidylinositol 3-kinase complex, class IB; ISS:UniProtKB GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; ISS:UniProtKB GO; GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; TAS:Reactome GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW GO; GO:0007186; P:G-protein coupled receptor signaling pathway; ISS:UniProtKB GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IBA:GO_Central GO; GO:0006661; P:phosphatidylinositol biosynthetic process; TAS:Reactome GO; GO:0030168; P:platelet activation; TAS:Reactome GO; GO:0045766; P:positive regulation of angiogenesis; IMP:UniProtKB GO; GO:0043406; P:positive regulation of MAP kinase activity; ISS:UniProtKB GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl GO; GO:0042269; P:regulation of natural killer cell mediated cytotoxicity; IDA:CACAO InterPro; IPR019522; PIK3R5/6 Pfam; PF10486; PI3K_1B_p101; 3 1: Evidence at protein level; Angiogenesis; Cell membrane; Complete proteome; Cytoplasm; Membrane; Reference proteome CHAIN 1 754 Phosphoinositide 3-kinase regulatory subunit 6 /FTId=PRO_0000234338 SEQUENCE 754 AA; 84258 MW; B7E3F1C2D422E2E6 CRC64; MESSDVELDL QRSVQAVLRE LSTQAPALQS NQGMWRWSLH KKVERDPGKS PVLVRILLRE LEKAESQDLR HVIIPLLHTV MYVLTKATGI TEELYQRIYA FCTRLLTLPT PYCTVALDCA IRLKTEMAVP GTLYQRMVIA EQNLTNELYP YQERVFLFVD PELVSASVCS ALLLEIEAAQ AQQTPETCMR HVVSHALQAA LGEACHAGAL HRKLQASPRR TLEHYFHAVV AALEQMASEA SPSREGHVER LEEIYCSLLG PAAGRCGGDL VQERPPSIPL PSPYITFHLW TGEEQLWKEL VLFLRPRSQL RLSADLEVLD LQGLRPDREL ARVSVLSTDS GIERDLPTGA DELPAPGSPE MERAGLQRKG GIKKRAWPLD FLMPGSWDGP PGLHRRTGRP SGDGEMLPGV SRLHTARVLV LGDDRMLGRL AQAYHRLRKR ETQKFCLTPR LSLQLYYIPV LAPEKPAASR QPELGELATF LGRVDPWYQS NVNTLCPAIH KLAEMPPSLD TSRTVDPFIL DVITYYIRMG TQPIYFQIYT VKIFFSDLSQ DPTEDIFLIE LKVKIQDSKF PKDGFSPRRR GVAEGPGAEL SLCYQKALLS HRPREVTVSL RATGLILKAI PASDTEVSGS SHCPLPAAPV TDHTCLNVNV TEVVKSSNLA GKSFSTVTNT FRTNNIQIQS RDQRLLTLSL DKDDQRTFRD VVRFEVAPCP EPCSGAQKSK APWLNLHGQQ EVEAIKAKPK PLLMPINTFS GIVQ
Research Areas
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Background

Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.

References

Voigt P.,et al.J. Biol. Chem. 281:9977-9986(2006).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Wilson L.S.,et al.J. Biol. Chem. 286:16285-16296(2011).

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$ 293.00
Cat# AI15951
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