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>   home   >   Products   >   Primary Antibodies   >   SLX1B Antibody - N-terminal region   

SLX1B Antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - SLX1B Antibody - N-terminal region AI15971

    Host: Rabbit
    Target Name: SLX1B
    Sample Tissue: Fetal Brain lysates
    Antibody Dilution: 1.0μg/ml
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9BQ83
Reactivity Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 30kDa
Additional Information
Gene ID 548593;79008
Other Names Structure-specific endonuclease subunit SLX1 {ECO:0000255|HAMAP-Rule:MF_03100}, 3.1.-.- {ECO:0000255|HAMAP-Rule:MF_03100}, GIY-YIG domain-containing protein 1 {ECO:0000255|HAMAP-Rule:MF_03100}, SLX1A {ECO:0000255|HAMAP-Rule:MF_03100}
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 &mu, l of distilled water. Final Anti-SLX1B antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsSLX1B Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLX1A {ECO:0000255|HAMAP-Rule:MF_03100}
Function Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.
Cellular Location Nucleus {ECO:0000255|HAMAP-Rule:MF_03100, ECO:0000269|PubMed:19596236}
Citations (0)

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Background

Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.

References

Martin J.,et al.Nature 432:988-994(2004).
Hildebrandt M.A.T.,et al.Biochem. Biophys. Res. Commun. 321:870-878(2004).
Svendsen J.M.,et al.Cell 138:63-77(2009).
Fekairi S.,et al.Cell 138:78-89(2009).
Munoz I.M.,et al.Mol. Cell 35:116-127(2009).

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$ 293.00
Cat# AI15971
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