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PDE10A Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9Y233 |
| Reactivity | Human, Rat, Rabbit, Horse, Dog |
| Predicted | Human, Rat, Rabbit, Horse, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 85kDa |
| Gene ID | 10846 |
|---|---|
| Alias Symbol | PDE10A, |
| Other Names | cAMP and cAMP-inhibited cGMP 3', 5'-cyclic phosphodiesterase 10A, 3.1.4.17, 3.1.4.35, PDE10A |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 &mu, l of distilled water. Final Anti-PDE10A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | PDE10A Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PDE10A |
|---|---|
| Function | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides (PubMed:10373451, PubMed:10393245, PubMed:16330539, PubMed:27058447, PubMed:17389385). Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (PubMed:10373451, PubMed:10393245, PubMed:27058447, PubMed:17389385). May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition (PubMed:27058447). |
| Cellular Location | Cytoplasm, cytosol |
| Tissue Location | Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.
References
Kotera J.,et al.Biochem. Biophys. Res. Commun. 261:551-557(1999).
Fujishige K.,et al.J. Biol. Chem. 274:18438-18445(1999).
Loughney K.,et al.Gene 234:109-117(1999).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
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