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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   CD6 Antibody - C-terminal region   

CD6 Antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • WB - CD6 Antibody - C-terminal region AI16097

    Host: Rabbit
    Target Name: CD6
    Sample Tissue: 721_B Whole Cell lysates
    Antibody Dilution: 1.0μg/ml
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P30203
Other Accession NP_006716
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 73kDa
Additional Information
Gene ID 923
Alias Symbol CD6,
Other Names T-cell differentiation antigen CD6, T12, TP120, CD6, CD6
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 &mu, l of distilled water. Final Anti-CD6 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsCD6 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD6
Function Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777).
Cellular Location Cell membrane; Single-pass type I membrane protein. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806) Colocalizes with the TCR/CD3 complex at the immunological synapse (PubMed:15294938).
Tissue Location Detected on thymocytes (PubMed:15294938). Detected on peripheral blood T-cells (PubMed:15048703, PubMed:16352806). Detected on natural killer (NK) cells (PubMed:16352806). Soluble CD6 is detected in blood serum (at protein level) (PubMed:17601777). Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes (PubMed:9013954). Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.
Research Areas
Citations (0)

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Background

Involved in cell adhesion. Binds to CD166.

References

Bowen M.A.,et al.J. Immunol. 158:1149-1156(1997).
Taylor T.D.,et al.Nature 440:497-500(2006).
Aruffo A.,et al.J. Exp. Med. 174:949-952(1991).
Castro M.A.,et al.J. Immunol. 178:4351-4361(2007).
Swack J.A.,et al.J. Biol. Chem. 266:7137-7143(1991).

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$ 293.00
Cat# AI16097
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