CNGB3 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9NQW8 |
Other Accession | NP_061971 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 88kDa |
Gene ID | 54714 |
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Alias Symbol | CNGB3, |
Other Names | Cyclic nucleotide-gated cation channel beta-3, Cone photoreceptor cGMP-gated channel subunit beta, Cyclic nucleotide-gated cation channel modulatory subunit, Cyclic nucleotide-gated channel beta-3, CNG channel beta-3, CNGB3 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 &mu, l of distilled water. Final Anti-CNGB3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
Precautions | CNGB3 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CNGB3 |
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Function | Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. |
Cellular Location | Membrane; Multi-pass membrane protein. |
Tissue Location | Expressed specifically in the retina. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
References
Kohl S.,et al.Hum. Mol. Genet. 9:2107-2116(2000).
Nusbaum C.,et al.Nature 439:331-335(2006).
Sundin O.H.,et al.Nat. Genet. 25:289-293(2000).
Shuart N.G.,et al.Nat. Commun. 2:457-457(2011).
Rojas C.V.,et al.Eur. J. Hum. Genet. 10:638-642(2002).
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