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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RGS1 Antibody - N-terminal region   

RGS1 Antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - RGS1 Antibody - N-terminal region AI16123

    Host: Rabbit
    Target Name: RGS1
    Sample Tissue: 721_B Whole Cell lysates
    Antibody Dilution: 1.0μg/ml
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q08116
Other Accession NP_002913
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 22kDa
Additional Information
Gene ID 5996
Alias Symbol RGS1, 1R20, BL34, IER1,
Other Names Regulator of G-protein signaling 1, RGS1, B-cell activation protein BL34, Early response protein 1R20, RGS1, 1R20, BL34, IER1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 &mu, l of distilled water. Final Anti-RGS1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsRGS1 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RGS1
Synonyms 1R20, BL34, IER1
Function Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541).
Cellular Location Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol
Tissue Location Detected in peripheral blood monocytes (PubMed:10480894). Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high (PubMed:8473738)
Research Areas
Citations (0)

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Background

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation.

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Hong J.X.,et al.J. Immunol. 150:3895-3904(1993).
Newton J.S.,et al.Biochim. Biophys. Acta 1216:314-316(1993).
Puhl H.L. III,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.

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$ 293.00
Cat# AI16123
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