CLIC2 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | O15247 |
Other Accession | NP_001280 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 27kDa |
Gene ID | 1193 |
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Alias Symbol | CLIC2, |
Other Names | Chloride intracellular channel protein 2, XAP121, CLIC2 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 &mu, l of distilled water. Final Anti-CLIC2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
Precautions | CLIC2 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CLIC2 |
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Function | Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. |
Cellular Location | Cytoplasm. Membrane; Single-pass membrane protein. Note=Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain |
Tissue Location | Expressed in adult and fetal brain, heart, skeletal muscle, liver, lung, and spleen. Detected in adult stomach and testis Expressed in fetal thymus and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.
References
Heiss N.S.,et al.Genomics 45:224-228(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ross M.T.,et al.Nature 434:325-337(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Fan L.,et al.FEBS Lett. 540:77-80(2003).
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