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>   home   >   Products   >   Primary Antibodies   >   Cardiovascular   >   HEY1 Antibody - C-terminal region   

HEY1 Antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • WB - HEY1 Antibody - C-terminal region AI16153

    Host: Rabbit
    Target Name: HEY1
    Sample Tissue: MCF7 Whole Cell lysates
    Antibody Dilution: 1.0μg/ml
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9Y5J3
Other Accession NP_036390
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 33kDa
Additional Information
Gene ID 23462
Alias Symbol HEY1, BHLHB31, CHF2, HERP2, HESR1, HRT1,
Other Names Hairy/enhancer-of-split related with YRPW motif protein 1, Cardiovascular helix-loop-helix factor 2, CHF-2, Class B basic helix-loop-helix protein 31, bHLHb31, HES-related repressor protein 1, Hairy and enhancer of split-related protein 1, HESR-1, Hairy-related transcription factor 1, HRT-1, hHRT1, HEY1, BHLHB31, CHF2, HERP2, HESR1, HRT1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 &mu, l of distilled water. Final Anti-HEY1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsHEY1 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HEY1
Synonyms BHLHB31, CHF2, HERP2, HESR1, HRT1
Function Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}
Tissue Location Expressed in the somitic mesoderm, the central nervous system, the kidney, the heart, nasal epithelium, and limbs
Research Areas
Citations (0)

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Background

Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'- CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.

References

Kokubo H.,et al.Biochem. Biophys. Res. Commun. 260:459-465(1999).
Leimeister C.,et al.Mech. Dev. 85:173-177(1999).
Steidl C.,et al.Genomics 66:195-203(2000).
Chin M.T.,et al.J. Biol. Chem. 275:6381-6387(2000).
Iso T.,et al.Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.

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$ 293.00
Cat# AI16153
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