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IBTK Antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • WB - IBTK Antibody - C-terminal region AI16161

    Host: Rabbit
    Target Name: IBTK
    Sample Tissue: 293T Whole Cell lysates
    Antibody Dilution: 1.0μg/ml
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9P2D0
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 148kDa
Additional Information
Gene ID 25998
Alias Symbol IBTK, BTKI, KIAA1417,
Other Names Inhibitor of Bruton tyrosine kinase, IBtk, IBTK, BTKI, KIAA1417
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 &mu, l of distilled water. Final Anti-IBTK antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsIBTK Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IBTK
Synonyms BTKI, KIAA1417
Function Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription.
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane upon IgM stimulation
Tissue Location Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues
Citations (0)

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Background

Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription.

References

Spatuzza C.,et al.Nucleic Acids Res. 36:4402-4416(2008).
Nagase T.,et al.DNA Res. 7:65-73(2000).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Mungall A.J.,et al.Nature 425:805-811(2003).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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$ 293.00
Cat# AI16161
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