TNFRSF10C antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | O14798 |
Other Accession | NM_003841, NP_003832 |
Reactivity | Human |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 25kDa |
Gene ID | 8794 |
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Alias Symbol | CD263, DCR1, LIT, MGC149501, MGC149502, TRAILR3, TRID, TRAIL-R3, DCR1-TNFR |
Other Names | Tumor necrosis factor receptor superfamily member 10C, Antagonist decoy receptor for TRAIL/Apo-2L, Decoy TRAIL receptor without death domain, Decoy receptor 1, DcR1, Lymphocyte inhibitor of TRAIL, TNF-related apoptosis-inducing ligand receptor 3, TRAIL receptor 3, TRAIL-R3, TRAIL receptor without an intracellular domain, CD263, TNFRSF10C, DCR1, LIT, TRAILR3, TRID |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-TNFRSF10C antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | TNFRSF10C antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TNFRSF10C |
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Synonyms | DCR1, LIT, TRAILR3, TRID |
Function | Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL- R1 and R2 for binding to the ligand. |
Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor. |
Tissue Location | Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart |
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
References
MacFarlane M.,et al.J. Biol. Chem. 272:25417-25420(1997).
Degli-Esposti M.A.,et al.J. Exp. Med. 186:1165-1170(1997).
Pan G.,et al.Science 277:815-818(1997).
Sheridan J.P.,et al.Science 277:818-821(1997).
Schneider P.,et al.FEBS Lett. 416:329-334(1997).
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