|Other Accession||NM_148967, NP_683868|
|Reactivity||Human, Mouse, Rat, Rabbit, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Bovine, Guinea Pig, Dog|
|Alias Symbol||APO-3, DDR3, DR3, LARD, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LR|
|Other Names||Tumor necrosis factor receptor superfamily member 25, Apo-3, Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, Death receptor 3, Lymphocyte-associated receptor of death, LARD, Protein WSL, Protein WSL-1, TNFRSF25, APO3, DDR3, DR3, TNFRSF12, WSL, WSL1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-TNFRSF25 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TNFRSF25 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||APO3, DDR3, DR3, TNFRSF12, WSL, WSL1|
|Function||Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 9: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted. Isoform 5: Secreted. Isoform 7: Secreted. Isoform 10: Secreted.|
|Tissue Location||Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
Kitson J.,et al.Nature 384:372-375(1996).
Chinnaiyan A.M.,et al.Science 274:990-992(1996).
Degli-Esposti M.A.,et al.Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
Marsters S.A.,et al.Curr. Biol. 6:1669-1676(1996).
Screaton G.R.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:4615-4619(1997).
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