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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   GPCR Antibodies   >   FFAR1 antibody - N-terminal region   

FFAR1 antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - FFAR1 antibody - N-terminal region AI16189

    WB Suggested Anti-FFAR1 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:12500
    Positive Control: Human Liver
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O14842
Other Accession NM_005303, NP_005294
Reactivity Human, Mouse, Rat, Pig, Bovine, Dog
Predicted Human, Mouse, Rat, Pig, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 31kDa
Additional Information
Gene ID 2864
Alias Symbol FFA1R, GPCR40, GPR40
Other Names Free fatty acid receptor 1, G-protein coupled receptor 40, FFAR1, GPR40
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-FFAR1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsFFAR1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FFAR1
Synonyms GPR40
Function G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Detected in brain and pancreas. Detected in pancreatic beta cells.
Research Areas
Citations (0)

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Background

G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.

References

Sawzdargo M.,et al.Biochem. Biophys. Res. Commun. 239:543-547(1997).
Briscoe C.P.,et al.J. Biol. Chem. 278:11303-11311(2003).
Tomita T.,et al.Biochem. Biophys. Res. Commun. 338:1788-1790(2005).
Sum C.S.,et al.J. Biol. Chem. 282:29248-29255(2007).
Sum C.S.,et al.J. Biol. Chem. 284:3529-3536(2009).

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$ 293.00
Cat# AI16189
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