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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   DOK2 antibody - C-terminal region   

DOK2 antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • WB - DOK2 antibody - C-terminal region AI16194

    WB Suggested Anti-DOK2 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:62500
    Positive Control: HepG2 cell lysate
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O60496
Other Accession NM_003974, NP_003965
Reactivity Human, Mouse, Rat, Pig, Horse, Bovine, Dog
Predicted Human, Mouse, Rat, Pig, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 45kDa
Additional Information
Gene ID 9046
Alias Symbol p56DOK, p56dok-2
Other Names Docking protein 2, Downstream of tyrosine kinase 2, p56(dok-2), DOK2
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-DOK2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsDOK2 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DOK2
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).
Tissue Location Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver.
Research Areas
Citations (0)

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Background

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).

References

Di Cristofano A.,et al.J. Biol. Chem. 273:4827-4830(1998).
Brill L.M.,et al.Anal. Chem. 76:2763-2772(2004).
Rush J.,et al.Nat. Biotechnol. 23:94-101(2005).
Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).

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$ 293.00
Cat# AI16194
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