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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   NFKBIA antibody - middle region   

NFKBIA antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - NFKBIA antibody - middle region AI16195

    WB Suggested Anti-NFKBIA Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:62500
    Positive Control: 293T cell lysate
  • WB - NFKBIA antibody - middle region AI16195
    Lanes: 1. 100 ug mouse heart lysate 2. 100 ug mouse kidney lysate 3. 100 ug mouse lung lysate 4. 100 ug mouse thymus lysate 5. 100 ug mouse spleen lysate
    Primary Antibody Dilution: 1:1000
    Secondary Antibody: Anti-rabbit-AP
    Secondary Antibody Dilution: 1:10000
    Gene Name: NFKBIA
    Submitted by: Andreia Carvalho, Instituto de Biologia Molecular e Celular, Universidade do Porto (IBMC-UP)/Organelle Biogenesis and Function (OBF) Group
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P25963
Other Accession NM_020529, NP_065390
Reactivity Human, Mouse, Rat, Pig, Sheep, Horse, Bovine, Dog
Predicted Human, Mouse, Rat, Pig, Sheep, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 35kDa
Additional Information
Gene ID 4792
Alias Symbol IKBA, MAD-3, NFKBI
Other Names NF-kappa-B inhibitor alpha, I-kappa-B-alpha, IkB-alpha, IkappaBalpha, Major histocompatibility complex enhancer-binding protein MAD3, NFKBIA, IKBA, MAD3, NFKBI
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-NFKBIA antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsNFKBIA antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NFKBIA
Synonyms IKBA, MAD3, NFKBI
Function Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Cellular Location Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
Research Areas
Citations (0)

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Background

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

References

Haskill S.,et al.Cell 65:1281-1289(1991).
Jungnickel B.,et al.J. Exp. Med. 191:395-402(2000).
Liu B.,et al.Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 293.00
Cat# AI16195
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