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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   GRIA2 antibody - N-terminal region   

GRIA2 antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - GRIA2 antibody - N-terminal region AI16208

    WB Suggested Anti-GRIA2 Antibody Titration: 2.5μg/ml
    ELISA Titer: 1:1562500
    Positive Control: HepG2 cell lysate
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P42262
Other Accession NM_000826, NP_000817
Reactivity Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig
Predicted Human, Mouse, Rat, Rabbit, Chicken, Horse, Bovine, Guinea Pig
Host Rabbit
Clonality Polyclonal
Calculated MW 99kDa
Additional Information
Gene ID 2891
Alias Symbol GLUR2, GLURB, GluA2, HBGR2, GluR-K2
Other Names Glutamate receptor 2, GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2, GRIA2, GLUR2
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 100 ul of distilled water. Final anti-GRIA2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsGRIA2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRIA2
Synonyms GLUR2
Function Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Cellular Location Cell membrane; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression
Research Areas
Citations (0)

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Background

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

References

Sun W.,et al.NeuroReport 5:441-444(1994).
Hillier L.W.,et al.Nature 434:724-731(2005).
Paschen W.,et al.J. Neurochem. 63:1596-1602(1994).
Kolleker A.,et al.Neuron 40:1199-1212(2003).
Dev K.K.,et al.J. Biol. Chem. 279:41393-41397(2004).

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$ 232.00
Cat# AI16208
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