|Other Accession||NM_002049, NP_002040|
|Reactivity||Human, Mouse, Rat, Rabbit, Sheep, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Sheep, Bovine, Guinea Pig, Dog|
|Alias Symbol||ERYF1, GF1, NFE1, GF-1, XLTT, GATA-1|
|Other Names||Erythroid transcription factor, Eryf1, GATA-binding factor 1, GATA-1, GF-1, NF-E1 DNA-binding protein, GATA1, ERYF1, GF1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-GATA1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||GATA1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781).|
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Provided below are standard protocols that you may find useful for product applications.
Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells.
Trainor C.D.,et al.Nature 343:92-96(1990).
Zon L.I.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:668-672(1990).
Ross M.T.,et al.Nature 434:325-337(2005).
Calligaris R.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:11598-11602(1995).
Boyes J.,et al.Nature 396:594-598(1998).
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