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YWHAB Antibody (C-term)Rabbit Monoclonal Antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1001a | 100ul 400 ul | 2-3 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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YWHAB Antibody (C-term) - Product info | |
| Application | WB, IHC
|
| Primary Accession | P31946 |
| Reactivity | Human, Mouse, Rat |
| Clone Names | Y62 |
| Calculated MW | 28082 Da |
| Gene ID 7529 | |
| Other Names YWHAB, 14-3-3 protein beta/alpha, N-terminally processed, Protein 1054 | |
| Target/Specificity A synthetic peptide corresponding to C-terminal residues of human 14-3-3 b/a was used as immunogen. | |
| Dilution WB~~1:1000~10000 IHC~~1:500 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions YWHAB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
YWHAB Antibody (C-term) - Protein Information | |
| Name YWHAB | |
| Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2 | |
| Cellular Location Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV | |
YWHAB Antibody (C-term) - Related products
AP8155a: YWHAB Antibody (N-term)
AP8155b: YWHAB Antibody (C-term)
RI15773: YWHAB predesign siRNA
LY11072a: YWHAB Over-expression Lysate
BP8155a: YWHAB (14-3-3 protein beta/alpha) Antibody (N-term) Blocking Peptide
BP8155b: YWHAB (14-3-3 protein beta/alpha) Antibody (C-term) Blocking Peptide
AT4558a: YWHAB Antibody (monoclonal) (M01)
YWHAB Antibody (C-term) - Application data
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A. Western blot analysis on Hela cell lysate using anti-14-3-3 b/a (C-term) RabMAb (Cat. #AJ1001a), dilution 1:1,000.
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B. Immunohistochemical analysis of paraffin-embedded breast tissue anti-14-3-3 b/a (C-term) RabMAb (Cat. #AJ1001a).
YWHAB Antibody (C-term) - Research Areas
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BACKGROUND
The 14-3-3 proteins are a family of proteins involved in the regulation of apoptosis, mitogenic signaling and cell-cycle checkpoints (1). The 14-3-3 proteins are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins (2,3). Through binding Bad, 14-3-3 prevents apoptosis by sequestering Bad to the cytosol (3).
REFERENCES
1. Fu, H., et al. 14-3-3 proteins: structure, function, and regulation. Ann. Rev. Pharmacol. Toxicol. 40: 617
2. Muslin, A.J. et al. Interaction of 14-3-3 with Signaling Proteins Is Mediated by the Recognition of Phosphoserine. Cell 84: 889
3. Zha, J. et al. Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL. Cell 87: 619
