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14-3-3E Antibody

Rabbit Monoclonal Antibody

  • WB - 14-3-3E Antibody AJ1001c
    Western blot analysis on (A) fetal brain, (B) SH-SY5Y, (C) 293T and (D) SW480 cell lysates using anti-14-3-3E RabMAb (Cat. #AJ1001c).
  • IF - 14-3-3E Antibody AJ1001c
    Immunofluorescent staining of HeLa cells using anti-14-3-3E RabMAb (Cat. #AJ1001c).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P62258
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR3918
Calculated MW 29174 Da
Gene ID 7531
Other Names 14-3-3 protein epsilon, 14-3-3E, YWHAE
Target/Specificity A synthetic peptide corresponding to residues in human 14-3-3E was used as an immunogen.
Dilution WB~~1:20000~100000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions14-3-3E Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Cellular Location Cytoplasm. Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Research Areas
Citations (0)

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The 14-3-3 epsilon protein (14-3-3E) is one of seven isoforms in the 14-3-3 protein family; a family which consists of acidic 30 kDa proteins expressed at high levels in neurons of the central nervous system (1). It is an adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. 14-3-3E binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (2). It also interacts with both, the insulin-like growth factor I receptor (IGFIR) and the insulin receptor substrate I (IRS-1), suggesting its role in the regulation of insulin sensitivity (3). 14-3-3E has also been implicated in the pathogenesis of small cell lung cancer (4).


1. Satoh J, et al. Am J Pathol. 165(2):577-92, 2004 2. The UniProt Consortium. The Universal Protein Resource (UniPro), Nucleic Acids Res. 36:D190-D195 (2008) 3. Craparo A, et al. J Biol Chem. 272(17):11663-9, 1997 4. NCBI Reference Sequence (RefSeq): a curated non- redundant sequence database of genomes, transcripts and proteins. Pruitt KD, Tatusova, T, Maglott DR Nucleic Acids Res 2007 Jan 1;35(Database issue):D61-5

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Cat# AJ1001c
(40 western blots)
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