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Aldh7A1 Antibody

Rabbit Monoclonal Antibody

     
  • WB - Aldh7A1 Antibody AJ1002b
    A.Western blot analysis on human liver lysate using anti-Aldh7a1 Rabbit Monoclonal (Cat. #AJ1002b).
  • IHC - Aldh7A1 Antibody AJ1002b
    B. Immunohistochemical analysis of paraffin-embedded human liver using anti-Aldh7a1 RabMAb (Cat. #AJ1002b).
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P49419
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names EP1935Y
Calculated MW 58487 Da
Gene ID 501
Other Names Alpha-aminoadipic semialdehyde dehydrogenase, Alpha-AASA dehydrogenase, Aldehyde dehydrogenase family 7 member A1, Antiquitin-1, Betaine aldehyde dehydrogenase, Delta1-piperideine-6-carboxylate dehydrogenase, P6c dehydrogenase, ALDH7A1, ATQ1
Target/Specificity A synthetic peptide corresponding to residues near the C-terminus of human Aldh7a1 was used as an immunogen.
Dilution WB~~1:1000
IHC~~1:100~250
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAldh7A1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALDH7A1
Synonyms ATQ1
Function Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.
Cellular Location Cytoplasm, cytosol. Nucleus
Tissue Location Abundant in hepatoma cells and fetal cochlea, ovary, eye, heart, adrenal gland, liver and kidney. Low levels present in adult peripheral blood leukocytes and fetal brain, thymus, spleen, skeletal muscle, lung and tongue
Research Areas
Citations (0)

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Background

Antiquitin (Aldh7a1) is an evolutionarily conserved protein believed to play a role in the regulation of cellular turgor. Based on sequence analysis, this protein is classified as a member of the aldehyde dehydrogenase superfamily (1). Analysis of the amount of mRNA in various rat and human tissues indicates that the largest amounts are found in rat kidney and liver and in cultured human hepatoma cells. Only minimal amounts were detected in human peripheral blood leukocytes, rat lung, or cultured human fibroblasts (2). The plant homolog of ATQ1 is thought to be involved in regulating turgor pressure, a function that also would be essential for cells of the mammalian cochlea. Northern blots of 13 human fetal tissues show antiquitin to be highly expressed in cochlea, ovary, eye, heart, and kidney (3).

References

1. Tang WK, et al. FEBS Lett 516(1-3):183-6, 2002
2. Lee P, et al. Genomics 21(2):371-8, 1994
3. Skvorak AB, et al. Genomics 46(2):191-9, 1997

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Discontinued
Cat# AJ1002b
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