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ACADM AntibodyRabbit Monoclonal IgG
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1007a | 100ul 400 ul | 2-3 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
ACADM Antibody - Product info | |
| Application | WB, IHC, IF
|
| Primary Accession | P11310 |
| Reactivity | Human, Mouse, Rat |
| Clone Names | EPR3708 |
| Calculated MW | 46588 Da |
| Gene ID 34 | |
| Target/Specificity A synthetic peptide corresponding to residues in human ACADM was used as an immunogen. | |
| Dilution WB~~1:1000~10000 IHC~~1:100~250 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ACADM Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
ACADM Antibody - Protein Information | |
| Name ACADM | |
| Function This enzyme is specific for acyl chain lengths of 4 to 16 | |
| Cellular Location Mitochondrion matrix. | |
ACADM Antibody - Related products
AP6827b: ACADM Antibody (C-term)
AP6827c: ACADM Antibody (Center)
BP6827b: ACADM Antibody (C-term) Blocking Peptide
BP6827c: ACADM Antibody (Center) Blocking Peptide
ACADM Antibody - Application data
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Western blot analysis on (A) human heart, (B) fetal liver, (C) HeLa, (D) HepG2, and (E) K562 cell lysates using anti-ACADM RabMAb (Cat. #AJ1007a).
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Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-ACADM RabMAb (Cat. #AJ1007a).
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Immunofluorescent staining of HeLa cells using anti-ACADM RabMAb (Cat. #AJ1007a).
ACADM Antibody - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Medium-chain specific acyl-CoA dehydrogenase (ACADM) is a homotetramer enzyme of the mitochondrial flavoenzyme family that catalyzes the initial reaction in medium chain fatty acid beta-oxidation (1, 2). ACADM is specific for acyl chain lengths of 4 to 16 (3). It utilizes the electron transfer flavoprotein (ETF) as an electron acceptor that transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (3). Defects in the ACADM gene cause medium-chain acyl-CoA dehydrogenase deficiency (MCADD), a metabolic disorder characterized by fasting hypoglycemia (3). Mutation analysis can diagnose MCADD, which is currently screened in newborns, since its monogene may be modified by genetic variations (4).
REFERENCES
1. Zhang et al. Biochemistry 31:81-89, 1992. 2. Battaile et al. Elsevier Science B.V., 1998. 3. The UniProt Consortium, The Universal Protein Resource (UniProt), Nucleic Acids Res. 37:D169-D174(2009). 4. Gregersen et al. Hum Mutat.18(3):169-89, 2001.
