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ACE AntibodyRabbit Monoclonal Antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1009a | 100ul 400 ul | 2-3 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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ACE Antibody - Product info | |
| Application | WB, IHC
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| Primary Accession | P12821 |
| Reactivity | Human, Mouse |
| Clone Names | EPR2757 |
| Calculated MW | 149715 Da |
| Gene ID 1636 | |
| Other Names ACE, DCP, DCP1, Angiotensin-converting enzyme, soluble form, Dipeptidyl carboxypeptidase I;Kininase II | |
| Target/Specificity A synthetic peptide corresponding to residues on the C-terminus of human ACE was used as an immunogen. | |
| Dilution WB~~1:1000~10000 IHC~~1:100~250 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ACE Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
ACE Antibody - Protein Information | |
| Name ACE | |
| Synonyms DCP, DCP1 | |
| Function Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety | |
| Cellular Location Angiotensin-converting enzyme, soluble form: Secreted | |
| Tissue Location Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis | |
ACE Antibody - Related products
AP7793b: ACE Antibody (C-term)
BP7793b: ACE Antibody (C-term) Blocking Peptide
ACE Antibody - Application data
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A. Western blot analysis on (A) fetal kidney, (B) fetal heart and (C) fetal lung lysates using anti-ACE (angiotensin converting enzyme) RabMAb (Cat. #AJ1009a), dilution 1:1000.
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B.Immunohistochemical analysis of paraffin-embedded human kidney using anti-ACE (angiotensin converting enzyme) RabMAb (Cat. #AJ1009a).
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C.Immunohistochemical analysis of paraffin-embedded spleen using anti-ACE (angiotensin converting enzyme) RabMAb Note positive staining of endothelial cells (Cat. #AJ1009a).
ACE Antibody - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Angiotensin-converting enzyme (ACE) is a zinc-containing dipeptidyl carboxypeptidase anchored in the plasma membrane with a carboxy-terminal hydrophobic domain (1, 2). ACE has a critical role in cardiovascular function because it catalyses the conversion of angiotensin I to the physiologically active vasopressor octapeptide angiotensin II, which controls fluid-electrolyte balance and systemic blood pressure (3, 4). Inhibitors of ACE are a first line of therapy for hypertension, heart failure, myocardial infarction and diabetic nephropathy (4). ACE also plays a critical role in the circulating or endocrine renin-angiotensin system (RAS) as well as the local regulation that exists in tissues such as the myocardium and skeletal muscle (5).
REFERENCES
1. Ehlers MR, et al. Proc Natl Acad Sci U S A. 86(20):7741-5,1989
2. Sugimura K, et al. Biochem Biophys Res Commun. 247(2):466-72, 1998
3. Rieder MJ, et al. Nat Genet. 22(1):59-62, 1999
4. Natesh R, et al. Nature. 421(6922):551-4, 2003
5. Natesh R, et al. Biochemistry. 43(27):8718-24, 2004
