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ACE Antibody

Rabbit Monoclonal Antibody

  • WB - ACE Antibody AJ1009a
    A. Western blot analysis on (A) fetal kidney, (B) fetal heart and (C) fetal lung lysates using anti-ACE (angiotensin converting enzyme) RabMAb (Cat. #AJ1009a), dilution 1:1000.
  • IHC - ACE Antibody AJ1009a
    B.Immunohistochemical analysis of paraffin-embedded human kidney using anti-ACE (angiotensin converting enzyme) RabMAb (Cat. #AJ1009a).
  • IHC - ACE Antibody AJ1009a
    C.Immunohistochemical analysis of paraffin-embedded spleen using anti-ACE (angiotensin converting enzyme) RabMAb Note positive staining of endothelial cells (Cat. #AJ1009a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P12821
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names EPR2757
Calculated MW 149715 Da
Gene ID 1636
Other Names Angiotensin-converting enzyme, ACE, 321-, Dipeptidyl carboxypeptidase I, Kininase II, CD143, Angiotensin-converting enzyme, soluble form, ACE, DCP, DCP1
Target/Specificity A synthetic peptide corresponding to residues on the C-terminus of human ACE was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsACE Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACE
Synonyms DCP, DCP1
Function Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
Cellular Location Angiotensin-converting enzyme, soluble form: Secreted
Tissue Location Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis
Research Areas
Citations (0)

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Angiotensin-converting enzyme (ACE) is a zinc-containing dipeptidyl carboxypeptidase anchored in the plasma membrane with a carboxy-terminal hydrophobic domain (1, 2). ACE has a critical role in cardiovascular function because it catalyses the conversion of angiotensin I to the physiologically active vasopressor octapeptide angiotensin II, which controls fluid-electrolyte balance and systemic blood pressure (3, 4). Inhibitors of ACE are a first line of therapy for hypertension, heart failure, myocardial infarction and diabetic nephropathy (4). ACE also plays a critical role in the circulating or endocrine renin-angiotensin system (RAS) as well as the local regulation that exists in tissues such as the myocardium and skeletal muscle (5).


1. Ehlers MR, et al. Proc Natl Acad Sci U S A. 86(20):7741-5,1989
2. Sugimura K, et al. Biochem Biophys Res Commun. 247(2):466-72, 1998
3. Rieder MJ, et al. Nat Genet. 22(1):59-62, 1999
4. Natesh R, et al. Nature. 421(6922):551-4, 2003
5. Natesh R, et al. Biochemistry. 43(27):8718-24, 2004

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Cat# AJ1009a
(40 western blots)
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