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Acetyl-CoA1 (ACC1) AntibodyRabbit Monoclonal Antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1010a | 100ul 400 ul | 2-3 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
Acetyl-CoA1 (ACC1) Antibody - Product info | |
| Application | WB, IHC
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| Primary Accession | Q13085 |
| Reactivity | Human, Mouse, Rat |
| Clone Names | EP687Y |
| Calculated MW | 265554 Da |
| Gene ID 31 | |
| Other Names ACACA, ACAC, ACC1, ACCA, Biotin carboxylase, ACC-alpha | |
| Target/Specificity A synthetic peptide corresponding to residues in the human Acetyl-CoA carboxylase 1 was used as an immunogen. | |
| Dilution WB~~1:500~2000 IHC~~1:50~100 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Acetyl-CoA1 (ACC1) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Acetyl-CoA1 (ACC1) Antibody - Protein Information | |
| Name ACACA | |
| Synonyms ACAC, ACC1, ACCA | |
| Function Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | |
| Cellular Location Cytoplasm. | |
| Tissue Location Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver | |
Acetyl-CoA1 (ACC1) Antibody - Related products
RI10039: ACACA predesign siRNA
AT1018a: ACACA Antibody (monoclonal) (M01)
Acetyl-CoA1 (ACC1) Antibody - Application data
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A. Western blot analysis on A431 cell lysate using anti-Acetyl-CoA carboxylase RabMAb (Cat. #AJ1010a), dilution 1:2000
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B. Immunohistochemical analysis of paraffin-embedded human liver using anti-AcetylCoenzyme A RabMAb (Cat. #AJ1010a).
Acetyl-CoA1 (ACC1) Antibody - Research Areas
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BACKGROUND
Acetyl-CoA carboxylase 1 (ACC1) is a biotin dependent lipogenic enzyme that is highly expressed during adipogenesis. ACC1 catalyzes acetyl-CoA carboxylation, producing malonyl-CoA, a metabolite involved in energy homeostasis regulation. Malonyl-CoA is a two carbon donor in the synthesis of long-chain fatty acids and the elongation of fatty acids found in the cystol (1). ACC1 is regulated short-term by citrate, CoA, and palmitoyl-CoA through allosteric interactions. Nutrients and hormones can be both short-term (inducing reversible phosphorylations by such as AMPK) and long-term (transcription level regulation) regulators of ACC1 (2). Highly expressed in lipogenic tissues, ACC1 is found in liver, adipose, and lactating mammary gland (3). ACC1 has been implicated as a target in the development of anti-obesity drugs (4).
REFERENCES
1. Jianqiang M, et al. PNAS 100:7515-7520, 2003.
2. Girad J, et al. The FASEB Journal 8:36-42, 1994.
3. Wakil SJ, et al. Annu Rev Biochem 52:537-539
4. Abu-Elheiga L, et al. Science 291: 2613-2616. 2001.
