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Acetyl-CoA1 (ACC1) Antibody

Rabbit Monoclonal Antibody

  • WB - Acetyl-CoA1 (ACC1) Antibody AJ1010a
    A. Western blot analysis on A431 cell lysate using anti-Acetyl-CoA carboxylase RabMAb (Cat. #AJ1010a), dilution 1:2000
  • IHC - Acetyl-CoA1 (ACC1) Antibody AJ1010a
    B. Immunohistochemical analysis of paraffin-embedded human liver using anti-AcetylCoenzyme A RabMAb (Cat. #AJ1010a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13085
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP687Y
Calculated MW 265554 Da
Gene ID 31
Other Names Acetyl-CoA carboxylase 1, ACC1, ACC-alpha, Biotin carboxylase, ACACA, ACAC, ACC1, ACCA
Target/Specificity A synthetic peptide corresponding to residues in the human Acetyl-CoA carboxylase 1 was used as an immunogen.
Dilution WB~~1:500~2000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAcetyl-CoA1 (ACC1) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ACAC, ACC1, ACCA
Function Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Cellular Location Cytoplasm.
Tissue Location Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver
Research Areas
Citations (0)

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Acetyl-CoA carboxylase 1 (ACC1) is a biotin dependent lipogenic enzyme that is highly expressed during adipogenesis. ACC1 catalyzes acetyl-CoA carboxylation, producing malonyl-CoA, a metabolite involved in energy homeostasis regulation. Malonyl-CoA is a two carbon donor in the synthesis of long-chain fatty acids and the elongation of fatty acids found in the cystol (1). ACC1 is regulated short-term by citrate, CoA, and palmitoyl-CoA through allosteric interactions. Nutrients and hormones can be both short-term (inducing reversible phosphorylations by such as AMPK) and long-term (transcription level regulation) regulators of ACC1 (2). Highly expressed in lipogenic tissues, ACC1 is found in liver, adipose, and lactating mammary gland (3). ACC1 has been implicated as a target in the development of anti-obesity drugs (4).


1. Jianqiang M, et al. PNAS 100:7515-7520, 2003.
2. Girad J, et al. The FASEB Journal 8:36-42, 1994.
3. Wakil SJ, et al. Annu Rev Biochem 52:537-539
4. Abu-Elheiga L, et al. Science 291: 2613-2616. 2001.

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Cat# AJ1010a
(40 western blots)
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