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ACHR-beta Antibody (extracellular)Rabbit Monoclonal Antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1011b | 100ul 400 ul | 2-3 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
ACHR-beta Antibody (extracellular) - Product info | |
| Application | WB
|
| Primary Accession | P11230 |
| Reactivity | Human, Mouse, Rat |
| Clone Names | EP2067Y |
| Calculated MW | 56698 Da |
| Gene ID 1140 | |
| Other Names CHRNB1, ACHRB, CHRNB, Acetylcholine receptor subunit beta | |
| Target/Specificity A synthetic peptide corresponding to residues in the extracellular region of human Acetylcholine receptor subunit beta was used as an immunogen. | |
| Dilution WB~~1:5000 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ACHR-beta Antibody (extracellular) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ACHR-beta Antibody (extracellular) - Protein Information | |
| Name CHRNB1 | |
| Synonyms ACHRB, CHRNB | |
| Function After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | |
| Cellular Location Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein | |
ACHR-beta Antibody (extracellular) - Application data
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A. Western blot analysis on human brain lysate using anti-ACHR-beta RabMAb (Cat. #AJ1011b), dilution 1:1000.
ACHR-beta Antibody (extracellular) - Related products
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The nicotinic acetylcholine receptor controls electrical signaling between nerve and muscle cells by opening and closing a gated, membrane-spanning pore. The gate is a constricting hydrophobic girdle at the middle of the lipid bi-layer, formed by weak interactions between neighboring inner helices. When acetylcholine enters the ligand-binding domain, it triggers rotations of the protein chains on opposite sides of the entrance to the pore (1). The widespread distribution of the beta subunit suggests it may serve as a common subunit in different AChR combinations in various brain regions. Regulation of the expression of beta subunit appears to be relatively unrestrained, with an apparent excess of protein synthesized in the cytoplasm relative to that which ultimately arrives at functional targets in the plasma membrane (2).
REFERENCES
1. Miyazawa A, et al. Nature 423(6943):949-55, 2003
2. Hill JA, et al. J Neurosci 13: 1551-68, 1993
