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Actopaxin/Parvin Antibody Phospho (pS8)

Rabbit Monoclonal Antibody

  • WB - Actopaxin/Parvin Antibody Phospho (pS8) AJ1013a
    A. Western blot analysis on A549 cell lysates using anti- Phospho-Actopaxin (pS8) RabMAb (Cat. #AJ1013a), 1:5000 dilution. Cells were either (A) untreated (B) treated with LP
  • IF - Actopaxin/Parvin Antibody Phospho (pS8) AJ1013a
    B. Immunofluorescent staining of HeLa cells using Phospho-specific anti-Actopaxin RabMAb (Cat. #AJ1013a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9EPC1
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR2174
Calculated MW 42330 Da
Gene ID 57342
Other Names Alpha-parvin, Actopaxin, Parva, Actp
Target/Specificity A phospho specific peptide corresponding to residues surrounding serine 8 of human Parvin was used as an immunogen. This antibody detects Actopaxin phosphorylated on serine 8.
Dilution WB~~1:5000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsActopaxin/Parvin Antibody Phospho (pS8) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Parva
Synonyms Actp
Function Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration. Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development.
Cellular Location Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line Note=Constituent of focal adhesions
Research Areas
Citations (0)

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Actopaxin (also named Parvin, Parva) is a member of the alpha actinin superfamily containing a single alpha-actinin-like actin-binding domain. The Parvin family plays a role in cell adhesion and cytoskeleton organization. Analysis of Actopaxin and its para- and orthologues suggest, that the parvins represent a new family of alpha-actinin-related proteins that mediate cell-matrix adhesion (1). Actopaxin is a widely expressed protein that binds directly to both F-actin and paxillin LD1 and LD4 motifs. It exhibits robust focal adhesion localization in several cultured cell types, but it is not found along the length of the associated actin-rich stress fibers. Actopaxin colocalizes with paxillin to rudimentary focal complexes at the leading edge of migrating cells. Results suggest an important role for actopaxin in integrin-dependent remodeling of the actin cytoskeleton during cell motility and cell adhesion (2).


1. Olski TM et al. J Cell Sci 114(Pt.3):525-38, 2001
2. Nikolopoulos SN et al. J Cell Biol 151(7) :1435-48, 2000

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Cat# AJ1013a
(40 western blots)
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