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Acyl thioesterase 1 Antibody

Rabbit Monoclonal

Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5675,063 and 7,429,487, owned by Abcam
Country
United States
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Ordering Information
Catalog # Size Availability Price  
AJ1014a 100µl 2-3 days $ 315.00 Add to cart
  • Specification
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Acyl thioesterase 1 Antibody - Product info

ApplicationWB
  • Applications Legend:
  • WB=Western Blotting
  • IP=Immunoprecipitation
  • IHC-P=Immunohistochemistry (Paraffin)
  • IF-IC=Immunofluorescence (Immunocytochemistry)
  • FC=Flow Cytometry
  • DB=Dot Blot
Primary AccessionO75608
ReactivityHuman, Mouse, Rat
Clone NamesEPR3666
Calculated MW24670 Da
Gene ID 10434
Other Names
LYPLA1, APT1, LPL1, Acyl-protein thioesterase 1, Lysophospholipase 1;Lysophospholipase I
Target/Specificity
A synthetic peptide corresponding to residues in human Acyl protein thioesterase 1 was used as an immunogen.
Dilution
WB~~1:5000~20000
Format
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
Acyl thioesterase 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Acyl thioesterase 1 Antibody - Protein Information

Name LYPLA1
Synonyms APT1, LPL1
Function
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity.
Cellular Location
Cytoplasm (By similarity).

Acyl thioesterase 1 Antibody - Related products

AP19062c: LYPLA1 Antibody (Center)

BP19062c: LYPLA1 Antibody (Center) Blocking Peptide

AJ1014b: Acyl thioesterase 1 Antibody

Acyl thioesterase 1 Antibody - Research Areas

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Provided below are standard protocols that you may find useful for product applications.

BACKGROUND

Acyl-protein thioesterase 1 (APT1, Lysophospholipase 1) is a member of a family of critical enzymes, lysophospholipases, that act on biological membranes to regulate the multifunctional lysophospholipids (1). APT1 hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (2). The role of APT1 in regulating lysophospholipids is important because increased levels of lysophospholipids are detected in a variety of diseases, including atherosclerosis and hyperlipidemia (1). Regulated expression of acyl-protein thioesterase by PKC has been suggested to have important implications for signal transduction processes (3).

REFERENCES

1. Wang A, et al. Biochim Biophys Acta. 1437(2):157-69, 1999 2. The UniProt Consortium, The Universal Protein Resource (UniProt). Nucleic Acids Res., 36:D190-D195 (2008) 3. Wang A, et al. Biochim Biophys Acta. 1484(2-3):207-14, 2000