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Adiponectin AntibodyRabbit Monoclonal Antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1017b | 100ul 400 ul | 2-3 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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Adiponectin Antibody - Product info | |
| Application | WB
|
| Primary Accession | Q15848 |
| Reactivity | Human |
| Clone Names | EPR3218 |
| Calculated MW | 26414 Da |
| Gene ID 9370 | |
| Other Names ADIPOQ, ACDC, ACRP30, APM1, GBP28, Adiponectin, Gelatin-binding protein | |
| Target/Specificity A synthetic peptide corresponding to residues in human Adiponectin was used as an immunogen. | |
| Dilution WB~~1:5000~10000 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Adiponectin Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Adiponectin Antibody - Protein Information | |
| Name ADIPOQ | |
| Synonyms ACDC, ACRP30, APM1, GBP28 | |
| Function Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW | |
| Cellular Location Secreted. | |
| Tissue Location Synthesized exclusively by adipocytes and secreted into plasma | |
Adiponectin Antibody - Related products
AP6531a: ACDC Antibody (N-term)
AP6531b: ACDC Antibody (C-term)
RI10144: ADIPOQ predesign siRNA
LY12086a: ADIPOQ Over-expression Lysate
BP6531a: ACDC Antibody (N-term) Blocking Peptide
Adiponectin Antibody - Application data
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A.Western blot analysis on (A) human fat and (B) human placenta and (C) human plasma lysates using anti-Adiponectin RabMAb (Cat. #AJ1017b), dilution 1:10,000.
Adiponectin Antibody - Research Areas
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BACKGROUND
Adiponectin is a multimeric adipocyte-specific secretory protein that regulates energy homeostasis, lipid metabolism, and insulin sensitivity with direct anti-diabetic, anti-atherogenic and anti-inflammatory properties. Adiponectin predominantly inhibits proliferation of myelomonocytic lineage cells and is an important negative regulator in hematopoiesis and immune systems (1, 2). Adiponectin is reported to possibly function as an endogenous factor involved in lipid catabolism and storage or whole body metabolism (3). It is decreased in obesity and has been demonstrated to inhibit tumor necrosis factor-alpha (TNF-alpha)-induced expression of endothelial adhesion molecules. Adiponectin modulates the inflammatory response of endothelial cells, possibly through cross talk between cAMP-PKA and NF-kappaB signaling pathways (4).
REFERENCES
1. Yokota T, et al. Blood 96(5):1723-32, 2000
2. Richards AA, et al. Mol Endocrinol. 20(7):1673-87, 2006
3. Nakano Y, et al. J Biochem. 120(4):803-12, 1996
4. Ouchi N, et al. Circulation. 102(11):1296-301, 2000
