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AGR2 Antibody

Rabbit Monoclonal Antibody

  • WB - AGR2 Antibody AJ1020b
    A. Western blot analysis on (A) HT-29 and (B) MCF-7 cell lysates using anti-AGR2 RabMAb (Cat. #AJ1020b), dilution 1:10,000.
  • IHC - AGR2 Antibody AJ1020b
    B.Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-AGR2 RabMAb (Cat. #AJ1020b).
  • IHC - AGR2 Antibody AJ1020b
    C.Immunohistochemical analysis of paraffin-embedded human endometrium adenocarcinoma using anti-AGR2 RabMAb (Cat. #AJ1020b).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95994
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3278
Calculated MW 19979 Da
Gene ID 10551
Other Names Anterior gradient protein 2 homolog, AG-2, hAG-2, HPC8, Secreted cement gland protein XAG-2 homolog, AGR2, AG2
Target/Specificity A synthetic peptide corresponding to residues in human AGR2 was used as an immunogen.
Dilution WB~~1:1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAGR2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AGR2
Synonyms AG2
Function Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth.
Cellular Location Secreted. Endoplasmic reticulum
Tissue Location Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines.
Research Areas
Citations (0)

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The anterior gradient protein-2 (AGR2) is a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen. It has been identified as a tumor marker in primary and secondary cancer lesions, and as a marker for detection of circulating tumor cells. Elevated levels of AGR2 are known to increase the metastatic potential of cancer cells (1). Specifically, AGR2 may serve as a useful molecular marker and/or potential therapeutic target for hormone-responsive breast tumours (2). AGR2 expression promotes tumor growth in esophageal adenocarcinoma cells and intestinal cells of secretory lineage, suggesting that AGR2 may be important for the growth and development of the intestine as well as esophageal adenocarcinomas (3).


1. Zweitzig DR, et al. Mol Cell Biochem. 306(1-2):255-60, 2007
2. Fletcher GC, et al. Br J Cancer 88(4):579-85, 2003
3. Wang Z, et al. Cancer Res. 68(2):492-7, 2008

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Cat# AJ1020b
(40 western blots)
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