|Reactivity||Human, Mouse, Rat|
|Calculated MW||105313 Da|
|Other Names||Catenin alpha-2, Alpha N-catenin, Alpha-catenin-related protein, CTNNA2, CAPR|
|Target/Specificity||A synthetic peptide corresponding to residues in human α-2 Catenin was used as an immungen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Alpha-2 Catenin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side Cell projection, axon. Note=Recruited to the nucleus upon ZNF639 overexpression|
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Provided below are standard protocols that you may find useful for product applications.
It has been shown that alpha N-catenin, a linker between cadherin adhesion receptors and the actin cytoskeleton, is essential for stabilizing dendritic spines in rodent hippocampal neurons in culture. Results suggest that alpha N-catenin is a key regulator for the stability of synaptic contacts (1). We show here that antibodies against alpha catenin also immunoprecipitate complexes that contain human N-cadherin, mouse P-cadherin, chicken A-CAM (adherens junction-specific CAM; also called N-cadherin) or Xenopus U-cadherin, demonstrating that alpha catenin is complexed with other cadherins (2).
1. Abe K, et al. Nat Neurosic 7(4):357-63, 2004
2. Herrenknecht K, et al. Proc Natl Acad Sci 88(20): 9156-60, 1991
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