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Alpha-2 Catenin Antibody

Rabbit Monoclonal Antibody

     
  • WB - Alpha-2 Catenin Antibody AJ1027a
    A. Western blot analysis on mouse brain lysate using anti-alpha 2 Catenin RabMAb (Cat. #AJ1027a), dilution 1:2000.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P26232
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR1795
Calculated MW 105313 Da
Gene ID 1496
Other Names Catenin alpha-2, Alpha N-catenin, Alpha-catenin-related protein, CTNNA2, CAPR
Target/Specificity A synthetic peptide corresponding to residues in human α-2 Catenin was used as an immungen.
Dilution WB~~1:2000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAlpha-2 Catenin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CTNNA2
Synonyms CAPR
Function May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q61301}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q61301}; Cytoplasmic side {ECO:0000250|UniProtKB:Q61301}. Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q61301}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q61301}. Cell projection, axon {ECO:0000250|UniProtKB:Q61301}. Nucleus
Research Areas
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Background

It has been shown that alpha N-catenin, a linker between cadherin adhesion receptors and the actin cytoskeleton, is essential for stabilizing dendritic spines in rodent hippocampal neurons in culture. Results suggest that alpha N-catenin is a key regulator for the stability of synaptic contacts (1). We show here that antibodies against alpha catenin also immunoprecipitate complexes that contain human N-cadherin, mouse P-cadherin, chicken A-CAM (adherens junction-specific CAM; also called N-cadherin) or Xenopus U-cadherin, demonstrating that alpha catenin is complexed with other cadherins (2).

References

1. Abe K, et al. Nat Neurosic 7(4):357-63, 2004
2. Herrenknecht K, et al. Proc Natl Acad Sci 88(20): 9156-60, 1991

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Discontinued
Cat# AJ1027a
Size:

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